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產(chǎn)品名稱：NecrosisInhibitor,Necrox-2
產(chǎn)品型號：
產(chǎn)品廠商：Biovision
產(chǎn)品文檔：

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NecrosisInhibitor,Necrox-2

詳情介紹：

Product details
Product details
Purpose	A necrosis inhibitor
Characteristics	A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1 μM NecroX-2 prevented ca. 50 % cell death in H9C2 cells exposed to 400 μM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro.
Purity	≥ 95?% by HPLC
Chemical Name	[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine
Formula	C??H??N?O?S?
Permeability	Cell-permeable
Solubility	DMSO (> 10 mg/mL)

Target details
Target details
Molecular Weight	516.67 g/mol

Application Details
Application Details
Restrictions	For Research Use only

Handling
Handling
Format	Solid
Handling Advice	Protect from light and moisture
Storage	-20 °C
Expiry Date	24 months

Images
Images
Supplier Images	Necrosis Inhibitor, Necrox-2 Necrosis Inhibitor, Necrox-2 Necrosis Inhibitor, Necrox-2

References
References
Product cited in:	Wang, Xiao, Ling, Meng, Wu, Yang, Zou: "BNIP3 upregulation by ERK and JNK mediates cadmium-induced necrosis in neuronal cells." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 140, Issue 2, pp. 393-402, 2014 (PubMed).

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